Investigating Biochemical Markers Variations and BMI in Patients with Diabetic Nephropathy: Insights from Baghdad Cohort Study
DOI:
https://doi.org/10.46649/s782he11Keywords:
Diabetes Mellitus, Renal Disease, Gfr, Body Mass Index (Bmi), Biochemical TestsAbstract
Abstract. Background: Diabetic nephropathy, or Diabetic kidney disease, is a long-term decline in kidney function that happens in individuals with diabetes mellitus. Diabetic nephropathy is the primary etiology of chronic kidney disease (CKD) and end-stage renal disease (ESRD).Emerging evidence indicates a possible association between body mass index and renal illness in individuals with type 2 diabetes mellitus.
Aim: the purpose of this research was to investigate the associations between changes in blood biochemical markers and body mass index in individuals diagnosed with type 2 diabetes and renal disease.
Material and method: we looked back at health records from Ibn Sina hospital in Baghdad, we studied the data from 80 participants and investigated during the months of July 2023 and October 2023, including 80 diagnosed with diabetes mellitus and renal disease following a comprehensive physical examination conducted by a specialist and biochemical tests. As a normal control for comparison with the patients' research group, an additional 40 adult volunteers who did not have diabetes or renal sickness were enlisted. We collected data about their age , gender, blood sugar level after fasting , insulin level, urea, creatinine, sodium, Glomerular filtration rate(GFR) and the percentage of sugar attach to their hemoglobin (HbA1C).
Results: The group of individuals with diabetes exhibited a significant decline in renal function, as well as elevated levels of insulin and HbA1C. The study findings demonstrate a statistically significant difference in Urea, Creatinine, Sodium, and GFR measures between the case and control groups among patients with pre-dialysis. The study results also showed that the body mass index (BMI) was nearly within the normal range for both groups, with a little rise noted in the male control group.
Conclusion: There was a notable association between body mass index and biochemical indicators in the blood plasma of patients suffering from both diabetes mellitus and renal failure, except for HbA1C and urea levels. All biochemical blood plasma indices display a consistent link, with a greater correlation observed among obese patients compared to those with normal body mass index values.
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