Association of IL-6 and IL-8 biomarker with hepatitis B virus in Iraqi patients
DOI:
https://doi.org/10.46649/abd3yk52Keywords:
Hepatitis B, Immunology, IL-6, IL-8.Abstract
Background: Hepatitis B virus (HBV) infection is a global health burden that contributes to liver inflammation, fibrosis, and hepatocellular carcinoma. Chemokines, such as IL-6 and IL-8, play critical roles in immune regulation, but their expression patterns and associations with HBV progression in Iraqi patients are poorly understood. Objectives: This study aimed to evaluate the potential association between serum concentrations of the biomarkers IL-6 and IL-8, and HBV infection among Iraqi patients.
Methods: A case-control study was conducted from September 2024 to February 2025, involving 100 participants (60 patients with HBV and 40 healthy controls) from the Al-Najaf Public Health Laboratory. Serum levels of IL-6 and IL-8 were quantified by ELISA.
Result: The current study revealed that the infection rate was in the age (20-70 years). HBV patients exhibited significantly elevated levels of IL-6 (The Mean±SE of IL-6 for patients group (10.591 ± 2.194), and the control group (1.307±0.285) with signtificant difference between two group (p value 0.0116).) and IL-8 (mean of patients group (227.006± 13.359) ), and the control group(82.410±9.676) With high significant difference betwen two group at P value < 0.0001)
Conclusion: This study demonstrated that the serum levels of IL-6 and IL-8 were significantly elevated in Iraqi patients with HBV. These findings highlight the potential clinical utility of chemokine profiling for managing HBV infection and advancing targeted therapeutic strategies
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