Estimation of Apolipoproteins with OxLDL in Male Patients with Hypertension.
DOI:
https://doi.org/10.46649/qy4ay262Keywords:
Obesity; Hypertension; Resistin; Apolipoproteins; Lipoproteins; Cardiovascular Diseases.Abstract
Background: Obesity and hypertension are critical risk factors for cardiovascular disease. Adipose tissue dysfunction in obesity promotes a pro-inflammatory, pro-atherogenic state via altered adipokine secretion (e.g., resistin), dyslipidemia, and increased oxidized low-density lipoprotein (OxLDL).
Aim: To investigate the correlation between serum resistin, Apolipoprotein A1 (ApoA1), Apolipoprotein B100 (ApoB100), and oxidized low-density lipoprotein (OxLDL) with body mass index (BMI) and lipid profiles in healthy, obese, hypertensive, and obese hypertensive males.
Material and Methods: In this case-control study of 60 males, serum resistin, ApoA1, ApoB100, and OxLDL were quantified by ELISA. Lipid profiles were determined using standard enzymatic methods. Relationships between biomarkers, BMI, and lipid parameters were assessed using Pearson’s correlation.
Results: BMI was positively correlated with OxLDL (r=0.507, p<0.001) and negatively correlated with ApoA1 (r=-0.403, p=0.001). Resistin was positively correlated with total cholesterol, triglycerides, LDL, and VLDL and negatively correlated with HDL. ApoB100 and OxLDL were positively correlated with atherogenic lipids, whereas ApoA1 was negatively correlated.
Conclusion: This study revealed a significant interplay among resistin, apolipoproteins, and OxLDL in the pro-atherogenic state associated with obesity. The strong correlations between these biomarkers and dyslipidemia underscore their potential as a composite panel for enhanced cardiovascular risk stratification in obese and hypertensive male patients.
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